Brenda L. Bass is a Distinguished Professor of

Biochemistry Biochemistry or biological chemistry is the study of chemical processes within and relating to living organisms. A sub-discipline of both chemistry and biology, biochemistry may be divided into three fields: structural biology, enzymology and ...

at the

University of Utah The University of Utah (U of U, UofU, or simply The U) is a public research university in Salt Lake City, Utah. It is the flagship institution of the Utah System of Higher Education. The university was established in 1850 as the University of De ...

who holds the H.A. and Edna Benning Endowed Chair. She is also an adjunct professor of human genetics and an investigator at the

Huntsman Cancer Institute Huntsman Cancer Institute (HCI) is an NCI-designated cancer research facility and hospital located on the campus of the University of Utah in Salt Lake City, Utah. It is the only National Cancer Institute-designated Comprehensive Cancer Center i ...

. Her research focuses on

RNA silencing RNA silencing or RNA interference refers to a family of gene silencing effects by which gene expression is negatively regulated by non-coding RNAs such as microRNAs. RNA silencing may also be defined as sequence-specific regulation of gene express ...

and the cellular dynamics of

double-stranded RNA Ribonucleic acid (RNA) is a polymeric molecule essential in various biological roles in coding, decoding, regulation and expression of genes. RNA and deoxyribonucleic acid ( DNA) are nucleic acids. Along with lipids, proteins, and carbohydr ...

. She was elected to the

National Academy of Sciences The National Academy of Sciences (NAS) is a United States nonprofit, non-governmental organization. NAS is part of the National Academies of Sciences, Engineering, and Medicine, along with the National Academy of Engineering (NAE) and the Nati ...

in 2015.

Education

Bass attended

Colorado College Colorado College is a private liberal arts college in Colorado Springs, Colorado. It was founded in 1874 by Thomas Nelson Haskell in his daughter's memory. The college enrolls approximately 2,000 undergraduates at its campus. The college offer ...

as an undergraduate and received a B.A. in chemistry in 1977. She was a graduate student at the

University of Colorado, Boulder The University of Colorado Boulder (CU Boulder, CU, or Colorado) is a public research university in Boulder, Colorado. Founded in 1876, five months before Colorado became a state, it is the flagship university of the University of Colorado syst ...

and received her Ph.D. under the supervision of

Thomas Cech Thomas Robert Cech (born December 8, 1947) is an American chemist who shared the 1989 Nobel Prize in Chemistry with Sidney Altman, for their discovery of the catalytic properties of RNA. Cech discovered that RNA could itself cut strands of RNA, ...

in 1985. She then worked as a

postdoctoral fellow A postdoctoral fellow, postdoctoral researcher, or simply postdoc, is a person professionally conducting research after the completion of their doctoral studies (typically a PhD). The ultimate goal of a postdoctoral research position is to p ...

with

Harold Weintraub Harold M. "Hal" Weintraub was an American scientist who lived from 1945 until his death in 1995 from an aggressive brain tumor. Only 49 years old, Weintraub left behind a legacy of research. Early life and education Born on June 2, 1945, in ...

at the

Fred Hutchinson Cancer Research Center The Fred Hutchinson Cancer Center, formerly known as the Fred Hutchinson Cancer Research Center and also known as Fred Hutch or The Hutch, is a cancer research institute established in 1975 in Seattle, Washington. History The center grew out o ...

from 1985 to 1989, where she discovered a class of

enzyme Enzymes () are proteins that act as biological catalysts by accelerating chemical reactions. The molecules upon which enzymes may act are called substrates, and the enzyme converts the substrates into different molecules known as products. A ...

s known as

ADAR Adar ( he, אֲדָר ; from Akkadian ''adaru'') is the sixth month of the civil year and the twelfth month of the religious year on the Hebrew calendar, roughly corresponding to the month of March in the Gregorian calendar. It is a month of 29 d ...

s (

-specific

adenosine Adenosine ( symbol A) is an organic compound that occurs widely in nature in the form of diverse derivatives. The molecule consists of an adenine attached to a ribose via a β-N9-glycosidic bond. Adenosine is one of the four nucleoside building ...

deaminase Deamination is the removal of an amino group from a molecule. Enzymes that catalyse this reaction are called deaminases. In the human body, deamination takes place primarily in the liver, however it can also occur in the kidney. In situations of ...

s).

Academic career and research

Bass joined the faculty at the

in 1989. She was named a Distinguished Professor in 2007 and given the H. A. and Edna Benning Chair in 2009. Research in Bass' laboratory focuses on

and the cellular dynamics of

(dsRNA) and double-stranded RNA binding proteins. She has continued to work with the ADAR enzymes she discovered during her postdoctoral work, as well as with

Dicer Dicer, also known as endoribonuclease Dicer or helicase with RNase motif, is an enzyme that in humans is encoded by the gene. Being part of the RNase III family, Dicer cleaves double-stranded RNA (dsRNA) and pre-microRNA (pre-miRNA) into short d ...

, a key

ribonuclease Ribonuclease (commonly abbreviated RNase) is a type of nuclease that catalyzes the degradation of RNA into smaller components. Ribonucleases can be divided into endoribonucleases and exoribonucleases, and comprise several sub-classes within the ...

enzyme in the RNA silencing pathway. The research group also studies how cells respond to long dsRNA molecules of likely viral origin, which may give rise to

inflammatory response Inflammation (from la, inflammatio) is part of the complex biological response of body tissues to harmful stimuli, such as pathogens, damaged cells, or irritants, and is a protective response involving immune cells, blood vessels, and molecu ...

s. Some of her work on

RNA interference RNA interference (RNAi) is a biological process in which RNA molecules are involved in sequence-specific suppression of gene expression by double-stranded RNA, through translational or transcriptional repression. Historically, RNAi was known by o ...

was the subject of an inventorship dispute initiated by the University of Utah involving patents by

Thomas Tuschl Thomas Tuschl (born June 1, 1966) is a German biochemist and molecular biologist, known for his research on RNA. Biography Tuschl was born in Altdorf bei Nürnberg. After graduating in Chemistry from Regensburg University, Tuschl received his P ...

licensed to

Alnylam Alnylam Pharmaceuticals, Inc. is an American biopharmaceutical company focused on the discovery, development and commercialization of RNA interference (RNAi) therapeutics for genetically defined diseases. The company was founded in 2002 and is he ...

; the lawsuit was not successful. Bass was an attendee at early meetings at

Cold Spring Harbor Laboratory Cold Spring Harbor Laboratory (CSHL) is a private, non-profit institution with research programs focusing on cancer, neuroscience, plant biology, genomics, and quantitative biology. It is one of 68 institutions supported by the Cancer Centers ...

that gave rise to the

RNA Society The RNA Society is a non-profit, international scientific society that serves to facilitate the dissemination of scientific results and concepts in ribonucleic acid (RNA) research. The society was founded in 1993 and currently consists of over 1 ...

, a

scientific society A learned society (; also learned academy, scholarly society, or academic association) is an organization that exists to promote an academic discipline, profession, or a group of related disciplines such as the arts and science. Membership may ...

for RNA researchers. The society publishes the journal ''

RNA Ribonucleic acid (RNA) is a polymeric molecule essential in various biological roles in coding, decoding, regulation and expression of genes. RNA and deoxyribonucleic acid ( DNA) are nucleic acids. Along with lipids, proteins, and carbohydra ...

'', on whose editorial board Bass has served since 1995. She also served as president of the society in 2007. Bass was a

Howard Hughes Medical Institute The Howard Hughes Medical Institute (HHMI) is an American non-profit medical research organization based in Chevy Chase, Maryland. It was founded in 1953 by Howard Hughes, an American business magnate, investor, record-setting pilot, engineer, fil ...

investigator from 1994 to 2009. She was elected to the

American Academy of Arts and Sciences The American Academy of Arts and Sciences (abbreviation: AAA&S) is one of the oldest learned societies in the United States. It was founded in 1780 during the American Revolution by John Adams, John Hancock, James Bowdoin, Andrew Oliver, and ...

in 2007, received the

National Institutes of Health Director's Pioneer Award National Institutes of Health Director's Pioneer Award is a research initiative first announced in 2004 designed to support individual scientists' biomedical research. The focus is specifically on "pioneering" research that is highly innovative ...

in 2011, and was elected a fellow of the

American Association for the Advancement of Science The American Association for the Advancement of Science (AAAS) is an American international non-profit organization with the stated goals of promoting cooperation among scientists, defending scientific freedom, encouraging scientific respons ...

the same year. In 2015, she was elected to the

References

{{DEFAULTSORT:Bass, Brenda L. Living people American women biochemists University of Utah faculty University of Colorado alumni Colorado College alumni Fellows of the American Academy of Arts and Sciences Fellows of the American Association for the Advancement of Science Members of the United States National Academy of Sciences Howard Hughes Medical Investigators Year of birth missing (living people) American women academics 21st-century American women